With the rapid development of information technology and the increasing complexity of global public health issues, the application of network platforms in higher education teaching has been expanding at an unprecedented speed and has gradually become indispensable. This paper will study in depth how to carry out teaching reform of the “Biosafety” course based on modern network platforms, address the current problems of traditional teaching models, such as old textbook content, inflexible instructional methods, and weak links between theory and practice. Guided by the outcome-based education (OBE) concept in the system of engineering education professional certification, all-round reform strategies are proposed in this paper. By systematically integrating rich digital network resources, innovating heuristic and case-based teaching methods, and building a multi-dimensional, continuous-improvement teaching evaluation system, a more efficient, highly interactive, and practical blended teaching system for “Biosafety” has been constructed. The construction of this reform will help students cultivate stronger self-study abilities and independent learning habits, improve their critical thinking and sense of social responsibility, thereby producing excellent all-round biosafety talents for the nation.