Global competence is not only a key ability for individuals in cross-cultural communication and global employment, but also the cornerstone for promoting social innovation and facilitating international cooperation and development. This paper quantitatively assesses students’ global competence through a combination of quantitative and qualitative research methods, based on the PCA and QPSO-BP models as algorithms. The assessment results show that the overall level of global competence of students in higher education institutions in Inner Mongolia is above average. Among all dimensions, except for attitude which is at a relatively high level, knowledge and skills all need to be improved. To make up for the above deficiencies, it is proposed to optimize the cultivation paths of global issues and topics from three aspects: interdisciplinarity, ideological and political education in courses, and practice. By training students’ logical thinking, critical thinking and creative thinking, the global competence of students can be enhanced.