With the continuous development of computer simulation technology and digital media art, the traditional digital media art interactive virtual simulation system can not meet the needs of users. This paper compares several mainstream system development software, selects Unity3D software to carry out the preliminary design work of the system, and finally designs a Unity-based interactive virtual simulation system for digital media art. However, in the process of system performance testing, it is found that the redundancy of the 3D model leads to excessive system response time, memory and CPU occupation, which directly and seriously affects the user experience. In response to this problem, the collapsing algorithm realizes the simplification of the 3D model by constructing the appropriate weighted error function, aiming at enhancing the performance of the system. After the three-dimensional model simplification, it is obvious that the CPU occupancy value is released, and its value is reduced from 0.5~0.7 to 0~0.35, which proves that the three-dimensional model simplification based on the edge folding algorithm is effective in optimizing the performance of the interactive virtual simulation system of the digital media art, so as to make it better serve the field of the digital media art. The research in this paper can provide theoretical guidance for the design and optimization of the interactive virtual simulation system of digital media art, so as to promote the high-quality development of the field of digital media art.