In particular, diseases occur in relation to immune function, and proper exercise is necessary to improve immunity. In this research, controlled experiments, mathematics, and statistics, as well as questionnaires, will be used to determine how physical fitness exercises relate to immune system function and disease occurrence. Firstly, a controlled experiment was conducted to determine the effects of physical fitness exercises on the immune system function. Secondly, correlation analysis was done to prove the relationship between the immune system function and physical fitness factors. Lastly, the correlation between physical fitness exercises and disease occurrence were determined based on exercise frequency, intensity, and duration. It was found that physical fitness exercises improved the immune system function and helped to maintain good health and reduce diseases. Exercise frequency, intensity, and duration have an effect on disease occurrence.