In order to realize the seismic optimum of steel frame structure, the influence of coupling effect of earthquake and corrosion is considered on the reliability. This paper presents an internal-and-external optimized design flow iterative process; the outer layer is used to optimize the model while the inner layer for analyzing the reliability. The optimization model is on the basis of “investment-benefit”, and its objective function is established by the linear weighted method. In addition, the reliability analysis is simulated by Monte Carlo method and the overall damage is calculated by the time-varying seismic damage model, which is used to evaluate the reliability and calculate the failure probability under different performance states. Finally, by the Visual studio 2010 software the optimization program is realized. As the increasing of the iterated times the total cost of structure decreases and converges to the optimal cost. The optimization is effective and feasible
