The tropical desert climate in the Middle East is characterized by extreme high temperatures, strong ultraviolet radiation and large diurnal temperature differences, which poses a severe challenge to the anti-rutting performance of asphalt pavement. Traditional asphalt materials are prone to softening and viscosity reduction under continuous high temperatures, causing permanent deformation of the road surface under heavy traffic. Rutting problems have become the core factor restricting the durability of roads in this area. Although existing studies have attempted to enhance high-temperature stability through means such as penetration regulation and polymer modification, they still have limitations in dealing with the complex stresses of desert climate (high temperature, ultraviolet rays, and dry-wet cycles). This study systematically evaluated the rutting resistance of stability-modified asphalt under extreme climates in the Middle East. Through laboratory simulation methods, the influence mechanisms of stabilizer type, dosage and climatic parameters on the high-temperature performance of asphalt mixtures were revealed. The experimental results show that the reasonable blending of stabilizers can significantly enhance the dynamic stability and anti-deformation ability of asphalt. Among them, inorganic stabilizers (such as lime and cement) perform better than organic stabilizers in high-temperature environments, while the composite stabilizer system further optimizes the material performance through synergistic effects. This study aims to reveal through experiments and theoretical analysis the improved anti-rutting ability of asphalt mixtures modified by various stabilizers under the tropical desert climate conditions in the Middle East, providing useful references for research and practice in related fields.