In order to alleviate the current employment pressure of undergraduate learners and promote the orderly social production, this paper digitizes the I&E education in colleges and universities, reforms the curriculum system of I&E education in colleges and universities and introduces the PBL teaching theory, and applies the digitized teaching mode based on PBL to the I&E education, which is aimed at enhancing the employment ability of undergraduate learners. This paper proposes the implementation approach of I&E education in digitalized colleges and universities, and tests the underlying mechanism role of the method of this paper with teaching experiments. The innovation and entrepreneurship practice ability of subjects in the experimental group and the control group did not differ significantly before the experiment (sig>0.05).After the experiment, the score difference of each dimension between the two groups widened to 10 points above and below, and the innovation and entrepreneurship practice ability of the experimental group was much higher than that of the control group, and the difference of each dimension was significant (sig<0.05).The intra-group difference between the experimental group before and after the experiment is significant (sig<0.05), and all dimensions have been improved more substantially, while the control group basically remains the same (sig>0.05).In this paper, the I&E education implementation approach of digitalized colleges and universities has a significant positive effect on improving undergraduate learners’ innovation and entrepreneurship practice ability.