As an independent geographic unit, a historic district is a cultural card of a city. However, in the process of urban renewal, the regionalized architectural features of historic districts are gradually lost, so it is urgent to re-examine the features of architectural features of historic districts and explore the design strategies for the integration of historic district preservation and modern architecture. The article firstly presents a reconstruction method of historical and cultural neighborhoods based on airborne LIDAR point cloud data. Then, it explores the method of extracting, converting and expressing the 3D digital information of the historic district, and integrates the modern architectural elements. Finally, the spatial syntax and color quantification methods are applied to analyze the landscape features and architectural colors of four historic districts in Jiangsu Province. Through the three-dimensional reconstruction experiment of an ancient building, the absolute value of the error of its architectural reconstruction accuracy result is within the range of 0-3cm, which verifies the validity of the historical neighborhood reconstruction method based on airborne LIDAR point cloud data. Through the numerical analysis of the spatial syntax of the four historic districts in Jiangsu Province, it is found that the average global integration degree and departmental integration degree of Historic District B is the highest, and its global integration degree is 1.9051. That is to say, Historic District B has a larger urban area, a rich road network, and the highest degree of recognition of historic districts. The method of this paper can provide some reference ideas for the integration design of historic district protection and modern architecture.