In the present research, the Workbench software platform was taken as the core tool to carry deep exploration on the creep fatigue coupling problem which is encountered by the steam generator heat transfer tubes of nuclear power plants in the process of long-time operation. This research specially adopts simulation analysis methods to uncover the structure damage principle of heat transfer pipes under high-temperature high-pressure bad environments, which is produced by the together actions of material aging and circular stress. The research outcomes show that the present research is capable of forecasting the behavior properties of heat transfer pipes in practical running, therefore offering firm theoretical assistance for the secure running of nuclear power stations. Besides this, the research outcomes can offer scientific foundation for maintenance methods and life evaluation of connected equipment, hence help related workers to more correctly forecast and handle equipment performance, and hence guarantee the safety and high efficiency of nuclear power stations.