Under the background of the deepening of “the integration of professional and creative”, entrepreneurship and innovation education in higher vocational colleges is faced with problems such as insufficient connection between curriculum content and professional scene, scattered resource allocation, poor school-enterprise collaboration, and experiential process evaluation, which restrict the overall effectiveness of education ecology. Around the above practical dilemma, this paper constructs the entrepreneurship and innovation education ecosystem in higher vocational colleges under the perspective of “integration of expertise and innovation”, introduces the methods of multi-source data perception, education ecological element identification, analytic hierarchy process evaluation and intelligent recommendation collaborative configuration, and integrates curriculum learning, project practice, competition training, enterprise tasks and platform services into a unified digital framework. By constructing an educational ecological element model and an evaluation model, this study structurally described students’ development status, resource supply characteristics and ecological operation quality, and realized the dynamic matching of curriculum resources, practical projects and tutor support with the help of an intelligent recommendation mechanism. The results show that the constructed educational ecosystem has good performance in operation efficiency and application effectiveness. The average response time of the platform is reduced to 1.6 s, the accuracy of resource matching is 91.3%, the task completion conversion rate is increased to 86.1%, and the comprehensive satisfaction is 90.2%. The research shows that the innovation and entrepreneurship education ecosystem supported by computer technology helps to improve the synergy, adaptation and continuous optimization ability of innovation and entrepreneurship education in higher vocational colleges, and can also provide reference for similar colleges to carry out digital innovation and entrepreneurship education reform.