This paper makes use of the RBF to calculate the interpolated displacement of vertexes on a 3D human body mesh. Through the integration of points of human body landmarks, lines, and customized measurements, a new 3D human body deformation model is created. At the same time, an RBF control point set is formed for the deformation of the 3D human body model. In addition, parametric cubic splines and bicubic surfaces patches are utilized to form a 3D garment model. This approach controls the constraints between 3D model parameters, enabling predictable control over the 3D prototype. Finally, garment design solutions under different methods are compared using SSIM, PSNR, and FID image evaluation metrics. The results show that 3D garment prototypes created using the method successfully imitate prototype designs, proving the usefulness of computer-aided garment designing solutions. The images produced through this method perform extremely well in all aspects and produce the best visual effects in garment designing.