As a combination of traditional Chinese style and modern design concepts, the new Chinese style is more concerned and loved by a wide range of people. This paper refers to the four methods of new Chinese style in villa space design, proposes the spatial decomposition method in virtual reality, and decomposes the subspace by this method, excludes a large amount of unreasonable data, and speeds up the calculation speed. On the basis of the immunogenetic algorithm, the immunity operator is added to ensure that the average affinity of individuals entering the next generation of the population is higher than that of the previous generation, and the immunogenetic algorithm is applied to optimize the solution processing of the data. In order to ensure the 3D visual comfort, after obtaining the parameters affecting the 3D perception, the scene brightness changes were realized by adjusting the camera exposure. ANOVA analysis of the satisfaction of the color scheme effect, the user’s satisfaction score for the color of the villa space designed by applying virtual reality technology is 4.87, and F=6.248, p=0.005 in the ANOVA, showing a significant difference. Referring to the spatial syntax index, among the specific indexes of the new Chinese villa space, the most obvious and prominent one is the landscape learning index, with an index score of 4.625, and the mean value of the spatial experience satisfaction of the villa space is 4.019, which indicates that the users have a better experience during the process of using the villa space.