Previous literature indicates that psychological resilience of university students could be affected by mental health education. It is necessary to explore the role of mental health education on psychological resilience. Emotion regulation strategies and self-esteem will be included in the research framework as mediators in the relation of mental health education and psychological resilience. Data will be collected via Adolescent Psychological Resilience Scale, Mental Health Education Curriculum Questionnaire, Emotional Regulation Strategies Questionnaire, and Rosenberg Self-Esteem Scale. Then, AMOS 24.0 will be used for data analysis to establish the structural equation model connecting mental health education, emotion regulation strategies, self-esteem, and psychological resilience. It is found out that overall mental health education is conducive to students’ psychological resilience through two paths: increased level of self-esteem and better emotion regulation strategies. Several model fit indicators were above 0.9, and thus the causal mechanism between variables was clearly identified. This study has verified the mediation effect of cognitive reappraisal and self-esteem, which provides sufficient evidence to develop curricula of mental health education at universities.