In order to assess the earthquake disaster risk of a regional water supply pipeline network, a basic database for seismic disaster risk analysis for the water supply pipeline network was established. Using the natural disaster risk model and the information entropy theory, a seismic disaster risk assessment model for the regional water supply pipeline network was proposed. Based on the basic data for the water supply pipeline network, an evaluation index system for a comprehensive earthquake resistance and vulnerability assessment was established. The classification criteria for the earthquake risk index of the regional water supply network were proposed. The vulnerability index and risk entropy index of the water supply network of each city were calculated and compared with the existing models. ArcGIS was used to calculate and draw a distribution map of the earthquake disaster risk entropy index of the water supply networks in mainland China. The regional differences were analyzed. Taking the earthquake damage caused by the Ms8.0 Wenchuan earthquake as an example, the reliability of the risk entropy model was verified.
